Since this is now confirmed a new universe, it's interesting that once again Karai is Shredder's daughter instead of being unrelated to him. This makes the fourth universe (after 4kids, Nick, and IDW), that Karai was Shredder's daughter, adopted daughter, or great great+ granddaughter.
At this rate Karai being related to Shredder is being cemented in canon in 4 different continuities. I guess ol' Mirage Karai is now the anomaly despite being the source material.
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