Pac-Man. Just off the top of my head - Atari 2600, Game Boy, Game Boy Color, the NES and Game Boy versions on 3DS, Wii U, Xbox 360, Xbox One, plus multiple compilations and with its pack-in as Pac-Man World for PS1 and on PS3.
Second would probably be Streets of Rage 2 (my actual favorite game ever). Genesis, Game Gear, 3DS, Wii, Steam, PS3, and Xbox 360.
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