In general, it depends on the hierarchy of the character. Primaries (the TMNT, Splinter, Shredder) should only change a moderate amount at most since their ultimate objectives have always been the most consistent. Becoming anti-heroes, traitors, or any other radical change just breaks up the harmony that makes those key characters so iconic. That's why most of the mutants work; a huge physical change with some personality changes, but outside of that, any other changes are moderate at best. However, characters that only appear a few times at most in a series are more fair for change, and while they won't be the same, I feel like that it can be the biggest thing that can happen to a minor character as opposed to being a monotonous one-or two-shot. Still, I feel that every character still should have a small amount of change (Even Leonardo!) to prove that they can change their strategies in battle to surprise others. Do you ever feel bored in real life? Its probably due to the inability to change once in awhile that you've grown stale, and so many series get cancelled due to that reason. You always need to change the proper amount to succeed but not enough to alienate.
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