I would kind of prefer it and it would seem a bit more reasonable that they were sneaky and somehow obtained DNA from those animals to use. Rather than, I dunno, stealing animals from the zoo?
At the same time though, if these two happen because Eric Sacks sets out to recreate the mutagen and make more mutants... How humans turn into another species would require more explanation when that wasn't what happened before.
Although personally, given how human these Turtles leaned, I wish they'd just go ahead and reveal that human DNA was involved to begin with with them. And I guess that way they could just claim to have recreated the mutagen but reversed the DNA part by using warthog and rhino DNA on humans this time.
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