On a Nickelodeon cartoon? Well what I would want to do with them would have to be filtered through that prism.
My whole premise would probably be akin to Palladium's "After the Bomb" universe. Ish. It's a few decades in the future and they're old (or they're a result of the bomb and young), there's lots of mutants for a very good reason, and we could get Game of Thrones-style (in a kids way) into all the hierarchies of mutants out there and the different politics therein. Like, there's a kingdom of knightly beavers in Oregon or something, who knows.
Otherwise on a TMNT kids show it has to be "w-w-we need to find a way to get mutagen out there everywhere, lots of mutants! Toys!" and they have to find hackneyed ways of doing that. I guess it's mosquitoes in the new show? I have no idea.
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