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Originally Posted by victory_angel
Exactly. Splinter would never really kill Shredder, the only times he attempted to do so was during Showdown and Owari. The other confrontations he has left Shredder alive partly because he is the only person from his past he truely has left. Yes there is Karai, but Karai was only a baby when Splinter knew her so she's just as much as a nuance in his life as the Turtles where she is currently.
Splinter also allows Shredder to live so that Karma can run its course or he still has some chance of seeking to redeem some honor, which would likely be performing sepuku.
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It is also worth noting that Splinters first reaction upon seeing Super Shredder was to respond with concern and offer to help him end his mutation, to which Shredder refused and attacked him.
I think the final nail in the coffin was in Requiem when Shredder's evil had taken him so far that he ordered Stockman to inject him with more mutagen that would ultimately destroy all emotional reaction within. That way, he had given up his soul for good and essentially was nothing but a mindless killing machine.
In his final confrontation with Leonardo, the Shredder seemed to hesitate when Leonardo asked him whether his destiny was to be a monster but then immediately started attacking again impulsively. Its as if his soul deep down was trapped and suffering in hell, unable to affect his body and regretful, but it was far too late to change as his body had become what his spirit was throughout the series, the embodiment of evil.