@winters While his armor mutated with him and became a fixed part of his person, the mask wasn't necessarily grafted to his skin. So his head just fell out when Leo picked up the helmet.
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Originally Posted by CyberCubed
Yeah Super Shredder was given extra mutagen formula and injections by Baxter in the last few episodes, it obviously made him immune to retro mutagen.
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I like to believe that Don's retromutagen weakened him enough to allow Leo the death blow.