IDW does have some human enemies but they're usually killed off quickly, like The Savate, the Asian gang in the Bebop/Rocksteady mini, there was Lupo and his men who worked for Dunn but they were all defeated by Casey's Purple Dragons.
I guess you can count Dr. Shelvin who works with Bishop, or even Winter/Knight since they're only loosely based on their old incarnations. Assuming Winter doesn't ever turn into a giant bug.
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