According to Deadline, Karai will be Shredder's (Mike Tee) daughter in this film.
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Brittany Ishibashi is suiting up for Teenage Mutant Ninja Turtles 2, Dave Green’s live-action sequel to last year’s hit reboot. She will play Shredder’s daughter Karai in the Paramount Pictures feature from Gama Entertainment Partners and Nickelodeon Movies.
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http://deadline.com/2015/05/brittany...lm-1201433321/
Comicbookmovie.com made a very good point.
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Karai's origins are never alluded to in the first movie, but there have been several variations of them over the years.
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http://www.comicbookmovie.com/fansit...news/?a=121023
I'm guessing that the Shredder in the last movie might have been her grandfather.