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I can't remember if it was stated outright that he wanted to BE human, but next mutation Michelangelo definitely wanted to at least integrate into human society. The cancelled film of the same title also had him having some kind of "look passingly human temporarily" power or such as a secondary mutation idea, I think.
There are a lot of examples of different turtles participating in human society in secret of course, like Donatello getting a mail-order college degree, or his tech support phone job. Really in the Imagi film at least 3 turtles are effectively secretly acting as humans to some degree.
I don't think the turtles becoming human has been this directly done before, because previous retro-mutagens and whatnot always just threatened to turn them into their original forms and not take them towards more human.
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