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Originally Posted by Splinter the boss
Nope, Leo is a mutant and Karai is human. Even if they were to get together, How would they be fruitful?
Personally I think Leo and Donnie are crazy(not actually crazy). I say to myself: "maybe they don't look at themselves in the mirror and see the extreme difference between them and the girls"
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I don't think they could reproduce but that still doesn't mean they can't be a couple.
Although I don't think the human/mutant thing is an issue. A couple don't have to be the same species in fantasy and sci-fi.
The most official couple in Babylon 5 Sheridan and Delenn were an interspecies couple with Sheridan being Human and Delenn was Minbari.
Although the fact they're adopted siblings and share some of the same DNA makes it a no go shipping for me.