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Well, TMNT 4 has smoother combat, since the controls in this game a just a little unresponsive. Mutant Nightmare isn't entirely a brawler, kind of an odd mix of the arcade games and the first NES game. The combat is similar to the arcades, especially since you can't progress further until you clear out all the enemies in a given area. The level design is more akin to the original NES game though. There's also a vehicle level in the first stage that changes depending on which Turtle you're playing as. Speaking of which, that does give the game some replay value, since each Turtle has a few different levels unique to each of them... and have different paths throughout the levels thery share. The boss fights are fairly fun and generally varied.
As for the touch screen... it's used for some little puzzles strewn throughout the levels and for initiating team moves involving the other Turtles or characters like Splinter and Karai in certain levels. Some team moves do damage and the others help your character progress through the level. Granted, team moves are also assigned to a button as well.
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