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Sara/Horridus is an alien. Her mother was a human, abducted by aliens and inseminated with Sara. Her mother died while giving birth and her father kept her locked in a basement with a TV until she was a teenager (hence why she's so socially awkward and always watching TV whenever we see her).
Mikey first met her very briefly in the second TMNT/Savage Dragon crossover (Savage Dragon #22).
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