I never thought about the 5 "sibling" aspect of Hamato Yoshi having a daughter before becoming Splinter and raising 4 sons. I really wonder how much older than the Turtles Hamato Jane will be. I do think it’d be an interesting dichotomy: (If) Shredder raised Yoshi's daughter and now she's his enemy and the Turtles might just be again tied to Shredder again (via the mutagen) and they are his enemy....trippy.
I look at the stuff we've been given and start trying to construct possible story ideas....makes me feel better....