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Old 03-25-2021, 12:03 AM   #1
Refractive Reflections
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AP News: UN Says New Polio Outbreak in Sudan Caused By Oral Vaccine

UN says new polio outbreak in Sudan caused by oral vaccine

By MARIA CHENG September 2, 2020


https://apnews.com/article/virus-out...f011b960a152e9
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LONDON (AP) — The World Health Organization says a new polio outbreak in Sudan is linked to an ongoing vaccine-sparked epidemic in Chad — a week after the U.N. health agency declared the African continent free of the wild polio virus.

In a statement this week, WHO said two children in Sudan — one from South Darfur state and the other from Gedarif state, close to the border with Ethiopia and Eritrea — were paralyzed in March and April. Both had been recently vaccinated against polio. WHO said initial outbreak investigations show the cases are linked to an ongoing vaccine-derived outbreak in Chad that was first detected last year and is now spreading in Chad and Cameroon.

“There is local circulation in Sudan and continued sharing of transmission with Chad,” the U.N. agency said, adding that genetic sequencing confirmed numerous introductions of the virus into Sudan from Chad.

WHO said it had found 11 additional vaccine-derived polio cases in Sudan and that the virus had also been identified in environmental samples. There are typically many more unreported cases for every confirmed polio patient. The highly infectious disease can spread quickly in contaminated water and most often strikes children under 5. In rare instances, the live polio virus in the oral vaccine can mutate into a form capable of sparking new outbreaks.

Last week, WHO and partners declared that the African continent was free of the wild polio virus, calling it “an incredible and emotional day.”

On Monday, WHO warned that the risk of further spread of the vaccine-derived polio across central Africa and the Horn of Africa was “high,” noting the large-scale population movements in the region. More than a dozen African countries are currently battling outbreaks of polio caused by the virus, including Angola, Congo, Nigeria and Zambia.

Amid the coronavirus pandemic, many of the large-scale vaccination campaigns needed to stamp out polio have been disrupted across Africa and elsewhere, leaving millions of children vulnerable to infection. In April, WHO and its partners reluctantly recommended a temporary halt to mass polio immunization campaigns, recognizing the move could lead to a resurgence of the disease. In May, they reported that 46 campaigns to vaccinate children against polio had been suspended in 38 countries, mostly in Africa, because of the coronavirus pandemic.

Some of the campaigns have recently been re-started, but health workers need to vaccinate more than 90% of children in their efforts to eradicate the paralytic disease.

Health officials had initially aimed to wipe out polio by 2000, a deadline repeatedly pushed back and missed. Wild polio remains endemic in Afghanistan and Pakistan; both countries also are struggling to contain outbreaks of vaccine-derived polio.
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Old 03-25-2021, 08:21 PM   #2
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So if I'm reading that correctly because medical people in Chad, Cameroon and Sudan have understandably put their focus on vaccinating people against Covid-19 they've grown lax in vaccinating people for polio which has allowed it to spread.

That's horrible for the people in those countries but I'm not sure that's the point you were trying to make.
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Old 03-25-2021, 10:01 PM   #3
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Not sure I was even aware that an oral vaccine was a thing. How do they disable a "live virus" to prevent it from causing infection in the first place?

If that bugger can mutate and then just take that vaccine as an express train to spreading around... oh hell no. Hope they get it back under control quickly. Last thing any country needs is two viruses running rampant.



That poor kid in that photo though. lol
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Old 03-25-2021, 10:08 PM   #4
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Quote:
Originally Posted by IndigoErth View Post
Not sure I was even aware that an oral vaccine was a thing. How do they disable a "live virus" to prevent it from causing infection in the first place?

If that bugger can mutate and then just take that vaccine as an express train to spreading around... oh hell no. Hope they get it back under control quickly. Last thing any country needs is two viruses running rampant.



That poor kid in that photo though. lol
They disrupt viral samples through heating, acid wash, or even by a soapy wash solution. It breaks down the active RNA as I understand it, and you are left with a viral "body" with the appropriate shape that your body learns to recognize like a puzzle piece for your immune system - a sort of primer.
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Old 03-26-2021, 02:07 PM   #5
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Huh, interesting.

Don't think I'd personally ever trust that method and sounds a little too Russian roulette if it can still mutate and cause problems, but interesting.
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Old 03-26-2021, 02:26 PM   #6
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Originally Posted by IndigoErth View Post
sounds a little too Russian roulette if it can still mutate and cause problems, but interesting.
Well, it's supposed to be disabled, so I can't help but wonder if some protocol wasn't followed in manufacturing the vaccine. I mean... if it is disabled, then it doesn't function and so cannot mutate.

But that's just what makes sense to me and at that point we've reached the limit of my knowledge about that stuff. So who knows?
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