An alien disguised as a wealthy entrepreneur and world-renowned scientist. He is also the adoptive father of seven children who were born under mysterious circumstances and have supernatural abilities. Inventor of The Televator, The Levitator, The Mobile Umbrella Communicator, and Clever Crisp cereal. Olympic gold medalist and recipient of the Nobel Prize for his work in the cerebral advancement of the chimpanzee. He was very cold in his raising of the children in that he refused to let the children call him father, instead preferring to be called The Monocle. Also, when speaking to the children, he addressed them by their number, which he gave them in order of usefulness to him. Hargreeves deprived them of any normal childhood, instead relentlessly training and manipulating them into a dysfunctional team of young superheroes known as the Umbrella Academy

The leader of the Umbrella Academy. As a child he possessed super-strength and greatly increased resilience. After a disastrous expedition to Mars, however, The Monocle had to transplant his head onto the body of a Martian gorilla. His Martian gorilla body can withstand the vacuum of space although his human head still requires a helmet. He often uses a jet-pack and his weapon of choice is a ray-gun. After his career with The Umbrella Academy he moved to the moon and lived at the Annihilation Control outpost to monitor for impending threats.

The reckless and rebellious member of the team; described by The Monocle as “an insolent brat.” He has the ability to hold his breath indefinitely and has demonstrated a strong affinity for knife-throwing. He and Luther have a very clear rivalry, and Diego seems unwilling to take orders from Luther. He is more of a Batman-like superhero in that he goes on regular patrols and can be seen taking down drug dealers and other street-level criminals. In his teenage years, he was the bass player in a band called the Prime-8s, with Body (Inspector Lupo's chimpanzee partner) and his sister Vanya.

Described by The Monocle as incredibly narcissistic. She has the ability to instantly alter reality by lying. After her career with the Umbrella Academy, she married her boyfriend Patrick and had a daughter named Claire. The couple has since divorced and Patrick has full custody of their daughter. She is romantically linked to her adopted brother, Spaceboy, however their love for each other is unconsummated as Spaceboy sees himself as somewhat of a monstrosity due to his Martian gorilla body.

Showcases a fretful, morbid temperament. His powers are levitation, telekinesis, and the ability to communicate with the dead, although his powers only work when he is not wearing shoes. He has the words "Hello" and "Goodbye" tattooed on his palms. It has been theorized by Dr. Pogo that he's been taking drugs since he was a teenager.

At the age of 10, the boy disappeared by traveling 50 years into the future, which seemed to hold no difficulty for him. Sir Reginald had warned him that he would never be able to go back but after spending years calculating the logistics he was able to travel back in time. He physically aged normally during his time in the future but upon returning to the past, he regained his 10-year-old appearance, despite his adoptive siblings now being 30. His body is apparently stuck in time and cannot age, as medical examinations prove that there are signs of neither cell growth nor death.

Possesses monsters from other dimensions under his skin (most often appearing as tentacles emerging from his torso). He is deceased, but no information regarding his death has been given. There is a memorial statue of him located in front of the Academy.

The most estranged member of the group, Vanya originally showcased no exceptional powers other than an interest in music. Vanya is known to have written a memoir detailing her life with the Umbrella Academy and her decision to leave.

Referred to as "Mom" by the members of the Umbrella Academy, and appears to be a partially animate plastic mannequin. Little information is given as to her origins.

A talking chimpanzee who worked for The Monocle. He was a source of warmth and support that the children never received from their adoptive father.

Ruthless mercenaries who are tasked with traveling through time to take out targets in different decades while working for a shadowy organization, the Temps Aeternalis. Though Hazel is a loyal company man who has enjoyed what he does for decades, the job starts to wear on him—which puts him at odds with his equally lethal partner, Cha-Cha.

An up-and-coming member of the city’s police department focused on solving a string of crimes in the city. Some might call her arrogant, but she gets the job done, and with charm. She plays by the book, but that doesn’t make her soft. Patch is set to butt heads with at least one member of the Umbrella Academy due to her stance on vigilante justice.