Must Every Thing be Connect to Mutagen?

[Luckyday]

Do you feel that having ghosts, demons, vampires and other monsters being connected to mutagen takes away the sense of wonder or can the sense of wonder can get even stronger if the magic gets explained?

I think that as long it's not treated as hand wave but instead as a concept to explore, it could bring a whole new dimension.

Like for example, in ancient times, natural events were explain as acts of the gods so maybe there are myths and legends of certain creatures of what we think are true but are misrepresent of actual fact and are sometimes a small part of a bigger picture.

Or use it as a gateway to explain the biology of said creatures and opens a category of mutants like type A for anthropomorphic mutants that mutated under the conditions of Multicellular organism that made recent contact with human dna. And type B for non organic base mutants like ICK or terminator roach.