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Shredder should remain human, he's already scarred for life both physically and mentally. Not to mention actually caring for Karai, especially the guilt for what happned to her. Leaving a human who hates humans is much more interesting than going down the 'well he hates humans anyway so what the hell lets mutate him'.
In fact, he is one of the only human bad guys which makes him even more interesting. To mutate him just like almost 'every' other character to an animal or god forbid super shredder (I was never a fan - just seems like a dumbed down hulk smash version of one of the most skilled, ruthless, deadly characters of all time) takes away from him not adds to him.
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